Tagged as: FDA rolling review

Intellia Initiates Rolling BLA Submission for In Vivo CRISPR Therapy in Hereditary Angioedema

On April 27, 2026, Intellia Therapeutics (“Intellia”) announced that it has begun a rolling submission of a biologics license application (BLA) to the FDA for lonvoguran ziclumeran (lonvo-z), an investigational therapy for hereditary angioedema (HAE). Lonvo-z, previously known as NTLA-2002, is designed as a one-time, outpatient-administered treatment using in vivo…

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